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GW-9662 is a potent and selective antagonist of full-length PPARγ
PNU-120596 attenuates the carrageenan-induced increase in levels of TNF-α and IL-6 within the hindpaw oedema
Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates
2004 Nov 1
InChiKey: RGYQPQARIQKJKH-UHFFFAOYSA-N
NVP-BSK805 Size:2mg solid GW-9662 is a potent andNVP BSK805 is a JAK2 inhibor, which displays more than 20 fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. In vivo, NVP BSK805 exhibited good oral bioavailability and a long half life. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba F3 JAK2(V617F) cell driven mouse mechanistic model. Furthermore, NVP BSK805 potently suppressed recombinant human